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International Consortium for
Advancing Research on TNBC

(Triple Negative Breast Cancer)

ICART is an international coalition of cancer researchers studying the biology of Triple Negative Breast Cancer (TNBC).


Rarer and often more aggressive than other types of breast cancer, TNBC disproportionately affects women of African origin. Its cells test negative for three important breast cancer drug targets – the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2 (HER2) – hence the “triple negative” name. Because of this, TNBC fails to respond to hormone-based and HER2-targeting treatments, which often results in worse patient outcomes.


We want to change things for TNBC patients. Individually, researchers from each laboratory in the Consortium are committed to understanding this complex disease. But together we can achieve so much more.


Through worldwide collaborations between academic and clinical researchers, by pooling resources and sharing expertise, ICART will help to significantly advance research into the complicated biology of TNBC, offering a brighter future for women all over the world.

By taking the knowledge and expertise in our individual research labs, and sharing this with the wider TNBC community, ICART empowers us to do more together than we can alone.
- Ritu Aneja, PhD, Georgia State University, ICART Co-Founder
To improve outcomes for TNBC patients, it is vital that we join hands to understand this disease better, identify new biomarkers and effective targeted treatments; in this way we hope to usher in the era of precision oncology for TNBC patients.
- Dr. Emad Rakha, University of Nottingham, ICART Co-Founder

Where in the world are we?


The ICART network currently represents TNBC researchers from 12 different laboratories from 10 institutions in 9 different countries on 4 continents of the world. Scientists who collaborate within and across national borders work more efficiently by reducing duplication of effort, more effectively by having access to shared knowledge, expertise, resources and data, and generate greater, global impact for their research.


Read more about the research being carried out ICART member institutions.

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